Yi Li’s Lab @Dali University

李毅, 副教授, 硕士生导师（招收研究生方向）。

具有电子信息工程（学士）、物理电子学（硕士）和生物化学与分子生物学（博士）的跨学科教育背景。

长期从事以蛋白质为核心的智能算法设计和生物实验验证相关研究。

主持项目

• 1 国家自然科学基金青年项目, 62003068, 基于深度学习的病毒包膜蛋白抗原特征研究, 2021.01至2023.12, 24万元, 在研, 主持

参与项目

• 3 国家自然科学基金委员会, 地区科学基金项目, 32160113, 中国西南地区大疣蛛科蜘蛛系统学研究, 2022-01-01 至 2025-12-31, 36万元, 在研, 参与
• 2 国家自然科学基金委员会, 地区科学基金项目, 31960198, HIV-1抗体中和表型差异的分子机制研究, 2020-01 至 2023-12, 33万元, 在研, 参与
• 1 国家自然科学基金委员会, 重大研究计划, 91631304, 大规模多态信息的细胞溯祖理论和统计分析方法, 2017-01 至 2019-12, 275万元, 已结题, 参与

学术文章

• 14 Yi Li, Yu-Chen Guo, Hong-Han Cheng, Xin Zeng, Xiao-Ling Zhang, Peng Sang, Ben-Hui Chen†, and Li-Quan Yang†. Deciphering gp120 sequence variation and structural dynamics in HIV neutralization phenotype by molecular dynamics simulations and graph machine learning. 2022. Proteins: Structure, Function, and Bioinformatics. Link [PDF] [SI] Src SCI, IF: 3.756, 中科院JCR三区

• 13 李毅, 李爽, 张晓玲, 曾新, 桑鹏, 杨力权†. 极端中和表型HIV包膜蛋白gp120的高温分子动力学模拟研究. 2022. 原子与分子物理学报. PDF

• 12 Qin Wang, Rong Fu, Hong-Han Cheng, Yi Li, and Shi-Yan Sui†. Analysis of the resistance of small peptides from Periplaneta americana to hydrogen peroxide-induced apoptosis in human ovarian granular cells based on RNA-seq. 2022. Gene. Link

• 11 李毅, 侯江春, 吴悦莎, 桑鹏, 杨力权†. HIV包膜糖蛋白gp120结构及其动态性的研究进展. 2020. 中国病原生物学杂志. PDF

• 10 Yi Li, Xiao-Ling Zhang, Xue Yuan, Jiang-Chun Hou, Peng Sang, and Li-Quan Yang†. Probing intrinsic dynamics and conformational transition of HIV gp120 by molecular dynamics simulation. 2020. RSC Advances. Link PDF SCI, IF: 3.119, 中科院JCR三区 Correction: Probing intrinsic dynamics and conformational transition of HIV gp120 by molecular dynamics simulation. https://doi.org/10.1039/D0RA90094J

• 9 Yi Li, Lei Deng, Jing Liang, Guang-Heng Dong, Yuan-Ling Xia, Yun-Xin Fu†, and Shu-Qun Liu†. Molecular Dynamics Simulations Reveal Distinct Differences in Conformational Dynamics and Thermodynamics between the Unliganded and CD4-Bound States of HIV-1 gp120. 2020. Physical Chemistry Chemical Physics. Link PDF SCI, IF: 3.43, 中科院JCR二区, Top期刊

• 8 Yi Li, Yu-Chen Guo, Xiao-Ling Zhang, Lei Deng, Peng Sang, Li-Quan Yang†, and Shu-Qun Liu†. CD4-Binding Obstacles in Conformational Transitions and Allosteric Communications of HIV gp120. 2020. Biochimica et Biophysica Acta BBA.-Biomembranes. Link PDF SCI, IF: 3.411, 中科院JCR二区

• 7 Li-Quan Yang, Yi-Rui Yin, Jian-Xin Shen, Yi Li, Shu-Qun Liu†, and Peng Sang†. Insight Derived from Molecular Dynamics Simulation into Cold-Adaptation Mechanism of Trypsins 2020. Journal of Biomolecular Structure and Dynamics. Link

• 6 Li-Quan Yang, Gui-Yuan Chen, Yi Li, Ruo-Peng Zhang, Shu-Qun Liu†, and Peng Sang†. Insight derived from molecular dynamics simulation into dynamics and molecular motions of cuticle-degrading serine protease Ver112. 2019. Journal of Biomolecular Structure and Dynamics. Link

• 5 Yi Li, Lei Deng, Li-Quan Yang, Peng Sang†, and Shu-Qun Liu†. Effects of CD4 Binding on Conformational Dynamics, Molecular Motions, and Thermodynamics of HIV-1 gp120. 2019. International Journal of Molecular Sciences. Link PDF SCI, IF: 4.556, 中科院JCR二区, Top期刊

• 4 Yuan-Ling Xia, Jian-Hong Sun, Shi-Meng Ai, Yi Li, Xing Du, Peng Sang, Li-Quan Yang, Yun-Xin Fu†, and Shu-Qun Liu†. Insights into the Role of Electrostatics in Temperature Adaptation: A Comparative Study of Psychrophilic, Mesophilic, and Thermophilic Subtilisin-like Serine Proteases. 2018. RSC Advances. Link

• 3 Yi Li#, Lei Deng#, Shi-Meng Ai, Peng Sang, Jing Yang, Yuan-Lin Xia, Zhi-Bi Zhang, Yun-Xin Fu†, and Shu-Qun Liu†. Insights into the Molecular Mechanism Underlying CD4-Dependency and Neutralization Sensitivity of HIV-1: A Comparative Molecular Dynamics Study on gp120s from Isolates with Different Phenotypes. 2018. RSC Advances. Link PDF SCI, 2018IF: 3.049, 中科院JCR三区

• 2 Xing Du, Peng Sang, Yuan-Ling Xia, Yi Li, Jing Liang, Shi-Meng Ai, Xing-Lai Ji, Yun-Xin Fu, and Shu-Qun Liu†. Comparative Thermal Unfolding Study of Psychrophilic and Mesophilic Subtilisin-like Serine Proteases by Molecular Dynamics Simulations. 2017. Journal of Biomolecular Structure and Dynamics. Link

• 1 Xing Du#, Yi Li#, Yuan-Ling Xia, Shi-Meng Ai, Jing Liang, Peng Sang, Xing-Lai Ji, and Shu-Qun Liu†. Insights into Protein–Ligand Interactions: Mechanisms, Models, and Methods. 2016. International Journal of Molecular Sciences. Link PDF SCI, 2016IF: 3.226, 中科院JCR三区, 高被引论文